The B12 Bomber

Just before taking a break for the Independence Day celebrations, I had my monthly appointment with my hematologist. Typically this is not a big deal, and I treat as a necessary means to a healthy life. However, this visit, brought forth new, unsettling news.

During my infusion/transfusion in the spring, a new set of blood tests were ordered to see if there was an underlying condition that we just weren't seeing that would attribute to the iron deficiencies. When I arrived at my appointment, another round of blood tests were ordered - typically, it takes only 3 tubes of blood for all my tests to be run - this time, they took 14 tubes. (Now, I only mention that because it always makes me laugh when I need my own blood so much and then they take so much)

Amongst these tubes, lied an answer. Albeit, not one I really expected, or wanted, to hear. The doctors determined that in combination with the iron deficiency, I have Autoimmune Pernicious Anemia (PA). If you just said "What is that?" - good for you, I did the exact same thing. Well, sure the kind doctor explained it, but did I really understand it? So, like a good patient, I took all of the information that was provided and did a little research at home. What I can confirm, based upon the doctor's report, because of the severity of the PA it is caused by a genetic disposition and not a nutritional deficiency.

PA is a rare blood disorder characterized by the inability of the body to properly utilize vitamin B12, which is essential for the development of red blood cells. Most cases result from the lack of the gastric protein known as intrinsic factor, without which vitamin B12 cannot be absorbed. (My blood system is also producing antibodies to B12 which means it's killing the vitamin as fast as I am injecting it.) (PA is pictured at right)

The symptoms of PA may include weakness, fatigue, an upset stomach, an abnormally rapid heartbeat (tachycardia), and/or chest pains. Considered a neurological disease, if left untreated, PA can lead to dementia and is fatal. This is where the news become unsettling. I watched my grandmother pass away due to a long struggle with Alzheimer's Disease, and prior to her passing, we already knew that her mother and grandmother likely passed from the same disease. This caused immediate concern because we know that in our family, Alzheimer's does affect the women and now, we wonder if PA could be a direct link to this disease. While PA is not routinely screened for and is easily masked by many other disorders, including IDA, we will be doing more research to see if there is a connection.

Going forward, I am on a strict B12 regimen and while I don't like giving myself shots, it is necessary - along with more doctors appointments of course. The biggest issue is treating the PA while keeping the iron in the blood system stable. The red blood cells are having an extremely difficult time functioning and with two forms of anemia associated with the red cells, my body is working double time just to function.

Transfusions may increase or stay stable - there is no crystal ball at this point but more waiting, testing, watching, and praying will be taking place.